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Trastuzumab emtansine Chemical Structure

Trastuzumab emtansine

Data Sheet For research use only. Not for human use.
Cat. No. :BCP30527CAS No. :1018448-65-1Purity:98%
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CAS No. 1018448-65-1 Cat. No. BCP30527
Name Trastuzumab emtansine
Synonyms Ado-trastuzumab emtansine;Kadcyla; trastuzumab-DM1; trastuzumab-MCC-DM1; trastuzumab-MCC-DM1 antibody-drug conjugate; T-DM1; PRO132365;
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Chemical Name
Formula M. Wt 148.5 kg/mol
Purity 98% Storage Store at 4-8°C
Description Trastuzumab emtansine is an antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surface surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers. Check for active clinical trials or closed clinical trials using this agent.
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