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Brivaracetam Chemical Structure

Brivaracetam

Data Sheet For research use only. Not for human use.
Cat. No. :BCP14251CAS No. :357336-20-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 357336-20-0 Cat. No. BCP14251
Name Brivaracetam
Synonyms UCB 34714;UCB-34714;UCB34714; Briviact;
SMILES
Chemical Name
Formula C11H20N2O2 M. Wt 212.29
Purity 98% Storage Store at 4-8°C
Description Brivaracetam has been tested in a comprehensive safety pharmacology, toxicology, developmental toxicology, and genotoxicity program. It is of low acute toxicity, target organ for toxic effects is the hepatobiliary tract. Carcinogenicity studies are ongoing. Human pharmacology studies have shown that brivaracetam has a half-life of 8 h and nearly complete bioavailability . CSD episodes were regularly elicited on slices upon delivery of calibrated KCl drops and were recorded via two micropipette electrodes. After control CSDs, the drug was added to the perfusion and five subsequent CSDs were elicited during drug perfusion. Effects were assessed via CSD amplitude (Ampl) and duration at half-amplitude (D(1/2)). BRV, 10 and 32 microM reduced the Ampl and transiently the D(1/2). Levetiracetam, 32 and 100 microM had no effect on either Ampl or D(1/2) . Brivaracetam bound selectively with 20 fold higher affinity than levetiracetam to SV2A . BRV produced a concentration-dependent inhibition of
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