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Trichostatin A Chemical Structure

Trichostatin A

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01776CAS No. :58880-19-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 58880-19-6 Cat. No. BCP01776
Name Trichostatin A
Synonyms TSA; (+)-Trichostatin A; Trichostatin A (R-isomer);
SMILES
Chemical Name
Formula C17H22N2O3 M. Wt 302.37
Purity 98% Storage Store at 4-8°C
Description Trichostatin A, also known as TSA, is a HDAC inhibitor. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
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