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Galunisertib Chemical Structure

Galunisertib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02173CAS No. :700874-72-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 700874-72-2 Cat. No. BCP02173
Name Galunisertib
Synonyms LY2157299; LY-2157299; LY 2157299;
SMILES
Chemical Name
Formula C22H19N5O M. Wt 369.42
Purity 98% Storage Store at 4-8°C
Description LY2157299 potently inhibits the TGFβ receptor signaling. LY2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. LY2157299 also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC. LY2157299 also promotes VEGF induced HUVEC cell migration. LY2157299 potentiates angiogenesis in the in vitro VEGF-stimulated cord formation assay. LY2157299 inhibits TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner. LY2157199 treatment stimulates hematopoiesis from primary MDS bone marrow specimens.In human glioblastoma (GBM) cells, LY2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD.
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