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CAL-101 Chemical Structure

CAL-101

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02532CAS No. :870281-82-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 870281-82-6 Cat. No. BCP02532
Name CAL-101
Synonyms Idelalisib;GS-1101;CAL 101;CAL101; GS1101; GS 1101;
SMILES
Chemical Name
Formula C22H18FN7O M. Wt 415.42
Purity 98% Storage Store at 4-8°C
Description CAL-101 is not sensitive to other PI3K class I subunits including p110α, p110β, and p110γ. CAL-101 specifically blocks Fc?R1 p110δ-mediated CD63 expression with an EC50 of 8 nM in primary basophil. CAL-101 exhibits greater activity in B-cell acute lymphoblastic leukemia (B-ALL) and chronic lymphocytic leukemia (CLL) cells compared with acute myeloid leukemia (AML) and myeloproliferative neoplasm (MPN) cells. CAL-101 produces the reduction in pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM. CAL-101 induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics, primarily through a caspase-dependent mechanism. CAL-101 induces cytotoxicity preferentially to CLL cells compared with normal B cells, without producing cytotoxicity in other hematopoietic cells, compared to LY294002. CAL-101 lacks direct cytotoxic potential to T cells and nature killer (NK) cells. CAL-101 can inhi
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