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Angiogenesis/Protein Tyrosine Kinase
c Kit

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c Kit

Chemical Structure Cat. No. Product Name CAS No.
Masitinib Mesylate Chemical Structure
BCP30695 Masitinib Mesylate 1048007-93-7
Masitinib Mesylate is a potent and selective tyrosine kinase inhibitor that targets KIT.
Avapritinib Chemical Structure
BCP20175 Avapritinib 1703793-34-3
Avapritinib is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.
AMG-25 Chemical Structure
BCP20632 AMG-25 1003311-62-3
AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.
AST-487 Chemical Structure
BCP21589 AST-487 630124-46-8
AST 487 is a RET kinase inhibitor with IC50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC50 of 520 nM.
PLX3397 HCl Chemical Structure
BCP29551 PLX3397 HCl 2040295-03-0
PLX-3397 HCl is a potent, selective and ATP-competitive CSF1R (cFMS) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Anti-cancer activity.
Ripretinib Chemical Structure
BCP29218 Ripretinib 1442472-39-0
DCC-2618 is a pan-KIT and PDGFRA inhibitor, and has antitumor activity.
Sitravatinib Chemical Structure
BCP29099 Sitravatinib 1123837-84-2
Sitravatinib (MGCD516,MG-516) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl.
ISCK03 Chemical Structure
BCP20053 ISCK03 945526-43-2
ISCK03 is a specific SCF/c-Kit inhibitor.
AZD-2932 Chemical Structure
BCP07984 AZD-2932 883986-34-3
AZD2932 is a new series of quinazoline ether inhibitor which potently inhibits VEGFR-2 and PDGFR with IC50s of 4 nM/8 nM/ 7 nM for PDGFRβ/VEGFR-2/Flt-3.
Flumatinib mesylate Chemical Structure
BCP08647 Flumatinib mesylate 895519-91-2
Flumatinib mesylate (HH-GV-678 mesylate), a derivative of imatinib, is a multi-kinase inhibitor with IC50 Values of 1.2 nM, 307.6 nM and 2662 nM for c-Abl, PDGFRβ and c-Kit respectively.
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