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Chemical Structure Cat. No. Product Name CAS No.
Shepherdin Chemical Structure
BCP42633 Shepherdin 861224-28-4
Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.
IPA-3 Chemical Structure
BCP42390 IPA-3 42521-82-4
IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
IMP-1088 Chemical Structure
BCP42030 IMP-1088 2059148-82-0
IMP-1088 is a novel potent and selective blocker of N-myristoylation in cells.
Belumosudil mesylate Chemical Structure
BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively). Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
GNE-6640 Chemical Structure
BCP41857 GNE-6640 2009273-60-1
GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death.
SIRT-IN-2 Chemical Structure
BCP41849 SIRT-IN-2 1431411-66-3
SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
AZD-5305 Chemical Structure
BCP41765 AZD-5305 2589531-76-8
AZD5305 is a potent and oral active, second-generation PARP (highly selective PARP1) inhibitor.
CDK4 inhibitor compound 12 Chemical Structure
BCP41586 CDK4 inhibitor compound 12 2105956-77-0
CDK4 inhibitor compound 12 is a novel inhibitor of CDK4 with the activity 97 μM.
Wee1 Inhibitor Chemical Structure
BCP41522 Wee1 Inhibitor 622855-37-2
Wee1 Inhibitor I is an ATP-binding site-targeting inhibitor of Wee1.
Berubicin Chemical Structure
BCP41505 Berubicin 677017-23-1
Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
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