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FTase

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FTase

Chemical Structure Cat. No. Product Name CAS No.
ABT-100 Chemical Structure
BCP42635 ABT-100 450839-40-4
ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.
FTI-276 TFA Chemical Structure
BCP37171 FTI-276 TFA 1217471-51-6
FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 nM and 0.5 nM for Plasmodium falciparum and human, respectively.
FTI-2153 Chemical Structure
BCP37169 FTI-2153 344900-92-1
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity.
FTI-277 hydrochloride Chemical Structure
BCP37166 FTI-277 hydrochloride 180977-34-8
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
FTI-277 Chemical Structure
BCP32847 FTI-277 170006-73-2
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
FTI-2148 Chemical Structure
BCP37168 FTI-2148 251577-09-0
FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively.
FTI-276 Chemical Structure
BCP37170 FTI-276 170006-72-1
FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human.
LB42708 Chemical Structure
BCP09683 LB42708 226929-39-1
LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
BMS-214662 hydrochloride Chemical Structure
BCP19824 BMS-214662 hydrochloride 195981-08-9
BMS-214662 is a potent and selective farnesyl transferase inhibitor with potent antitumor activity with an IC50 of 1.35 nM.
Lonafarnib Chemical Structure
BCP07027 Lonafarnib 193275-84-2
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.
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