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mGluR

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mGluR

Chemical Structure Cat. No. Product Name CAS No.
LY487379 Chemical Structure
BCP39937 LY487379 353231-17-1
LY 487379 is a positive allosteric modulator selective for mGluR-2.
VU 0409551 Chemical Structure
BCP39846 VU 0409551 1363281-27-9
VU0409551 is a selectively glutamate receptor subtype 5 (mGlu5) positive allosteric modulator with EC50 value of 260 nM. VU0409551 shows distinct stimulus bias and selectively potentiates mGlu5 coupling to Gαq-mediated signaling. It exhibits wake-promoting, antipsychotic-like and cognition-enhancing effects in animal models.
VU0155094 Chemical Structure
BCP38019 VU0155094 731006-86-3
VU0155094 is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively.
AZD-8529 mesylate Chemical Structure
BCP37624 AZD-8529 mesylate 1314217-69-0
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
AZD-8529 Chemical Structure
BCP37625 AZD-8529 1092453-15-0
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
Decoglurant Chemical Structure
BCP33908 Decoglurant 911115-16-7
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.
YM 298198 Hydrochloride Chemical Structure
BCP33084 YM 298198 Hydrochloride 748758-45-4
YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM).
NPS 2390 Chemical Structure
BCP33083 NPS 2390 226878-01-9
NPS2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors.
SIB 1893 Chemical Structure
BCP33034 SIB 1893 6266-99-5
SIB-1893 is a selective non-competitive antagonist of the metabotropic glutamate mGlu5 receptor subtype.
SIB 1757 Chemical Structure
BCP33033 SIB 1757 31993-01-8
SIB-1757 is a highly selective antagonist for the mGlu5 metabotropic glutamate receptor subtype. SIB-1757 displays an IC50 value of 0.4 μM at hmGlu5 compared with > 30 μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7 and hmGlu8.
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