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Mps1

Chemical Structure Cat. No. Product Name CAS No.
BOS-172722 Chemical Structure
BCP31542 BOS-172722 1578245-44-9
BOS172722 is a potent and selective MPS1 inhibitor with IC50 = 11 nM. BOS172722 showed very good bioavailability in all three species despite very modest solubility at physiological pH. Monopolar spindle 1 (MPS1) occupies a central role in mitosis and is one of the main components of the spindle assembly checkpoint. The MPS1 kinase is an attractive cancer target.
MPS1-IN-3 Chemical Structure
BCP37980 MPS1-IN-3 1609584-72-6
MPS1-IN-3 is a selective and potent MPS1 inhibitor with phenotypic consequences similar to those reported for published MPS1 inhibitors such as MPS1-IN-1, MPS1-IN-2, and AZD3146.
CFI-402257 Chemical Structure
BCP31204 CFI-402257 1610759-22-2
CFI-402257 is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 has anti-cancer activity.
Mps1-IN-1 Chemical Structure
BCP27688 Mps1-IN-1 1125593-20-5
Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM.
MPI-0479605 Chemical Structure
BCP27897 MPI-0479605 1246529-32-7
MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
Mps1-in-2 Chemical Structure
BCP19164 Mps1-in-2 1228817-38-6
Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.
CCT251455 Chemical Structure
BCP10514 CCT251455 1400284-80-1
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.
AZ3146 Chemical Structure
BCP02545 AZ3146 1124329-14-1
AZ3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM).
NMS-P715 analog Chemical Structure
BCP28300 NMS-P715 analog 1202055-34-2
NMS-P715 analog is an inhibitor of MPS1, with an IC50 of 84 nM.
NMS-P715 Chemical Structure
BCP28244 NMS-P715 1202055-32-0
NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
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