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PDGFR

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PDGFR

Chemical Structure Cat. No. Product Name CAS No.
PD089828 Chemical Structure
BCP37851 PD089828 179343-17-0
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC50s=0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC50=0.18 μM). PD-089828 also inhibits MAPK with an IC50 of 7.1 μM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
CGP-53716 Chemical Structure
BCP34642 CGP-53716 152459-94-4
CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR.
Tyrosine kinase-IN-1 Chemical Structure
BCP30849 Tyrosine kinase-IN-1 705946-27-6
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
Sennoside B Chemical Structure
BCP14631 Sennoside B 128-57-4
Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation.
Masitinib Mesylate Chemical Structure
BCP30695 Masitinib Mesylate 1048007-93-7
Masitinib Mesylate is a potent and selective tyrosine kinase inhibitor that targets KIT.
Olaratumab Chemical Structure
BCP30495 Olaratumab 1024603-93-7
Olaratumab is a monoclonal antibody for the treatment of solid tumors.
Vorolanib Chemical Structure
BCP30430 Vorolanib 1013920-15-4
Vorolanib, also known as CM-082 and X-82, is small molecule dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and platelet-derived growth factor receptors (PDGFRs) with antiangiogenic and antineoplastic activities.
N-Desethyl Sunitinib Chemical Structure
BCP20914 N-Desethyl Sunitinib 356068-97-8
N-Desethyl Sunitinib is a metabolite of sunitinib.
JNJ-10198409 Chemical Structure
BCP08276 JNJ-10198409 627518-40-5
JNJ-10198409, also known as RWJ-540973, is an inhibitor of PDGF-BB tyrosine kinase with an IC50 value of 4.2 nM.
SU 4312 Chemical Structure
BCP20743 SU 4312 5812-07-7
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 = 0.8 and 19.4 μM, respectively) wirth selectivity over EGFR and c-Src tyrosine kinases.
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