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Phosphodiesterase/PDE

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Phosphodiesterase/PDE

Chemical Structure Cat. No. Product Name CAS No.
Zaprinast Chemical Structure
BCP38400 Zaprinast 37762-06-4
Zaprinast is an inhibitor of the growth of asexual blood-stage malaria parasites (P. falciparum). It acts by inhibiting PfPDE1 and activating GPR35.
HA-155 Chemical Structure
BCP37817 HA-155 1229652-22-5
HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine.
ATX inhibitor 1 Chemical Structure
BCP37626 ATX inhibitor 1 2225892-70-4
ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.
THPP-1 Chemical Structure
BCP37557 THPP-1 1257051-63-0
THPP-1 is a potent and orally bioavailable PDE10A inhibitor.
AMG 579 Chemical Structure
BCP36114 AMG 579 1227067-61-9
AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).
Mardepodect hydrochloride Chemical Structure
BCP35070 Mardepodect hydrochloride 2070014-78-5
Mardepodect hydrochloride is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier.
Zatolmilast Chemical Structure
BCP34899 Zatolmilast 1606974-33-7
Zatolmilast(BPN14770) is a phosphodiesterase IV inhibitor.
Deltasonamide 2 Chemical Structure
BCP34859 Deltasonamide 2 2088485-34-9
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor.
PF 04449613 Chemical Structure
BCP25929 PF 04449613 1236858-52-8
PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM).
Drotaverine hydrochloride Chemical Structure
BCP32864 Drotaverine hydrochloride 985-12-6
Drotaverine Hydrochloride is an antispasmodic drug, used to enhance cervical dilation during childbirth.
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