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RAR/RXR

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RAR/RXR

Chemical Structure Cat. No. Product Name CAS No.
EC23 Chemical Structure
BCP38021 EC23 104561-41-3
EC23 is a fluorescent, voltage, indicator, action, potentials, mammalian, neurons, perturbations, cardiac, waveform, pluripotent, stem, cell-derived, cardiomyocytes
BMS453 Chemical Structure
BCP37819 BMS453 166977-43-1
BMS453, a synthetic retinoid, is an RARβ agonist and an RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
AGN193109 Chemical Structure
BCP34864 AGN193109 171746-21-7
AGN193109 is a retinoic acid receptor (RAR) antagonist.
Bigelovin Chemical Structure
BCP34451 Bigelovin 3668-14-2
Bigelovin has been shown to cause cell cycle arrest and subsequently induce apoptosis in cancer cells. It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
Trifarotene Chemical Structure
BCP31392 Trifarotene 895542-09-3
Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively.
Etretinate Chemical Structure
BCP31125 Etretinate 54350-48-0
Etretinate is a RAR and RXR agonist previoulsy used to treat psoriasis. It induces brth defects and suppresses proliferation in cutaneous T-cell lymphoma models.
WYC-209 Chemical Structure
BCP31032 WYC-209 2131803-90-0
WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway
AGN 190299 Chemical Structure
BCP07476 AGN 190299 118292-41-4
Tazarotenic acid is a thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene. It has a role as a keratolytic drug and a teratogenic agent. It is a monocarboxylic acid, a thiochromane, a retinoid and a member of pyridines.
UVI3003 Chemical Structure
BCP30351 UVI3003 847239-17-2
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.
LG100268 Chemical Structure
BCP08283 LG100268 153559-76-3
LG100268 is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
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