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TGF beta/Smad

Chemical Structure Cat. No. Product Name CAS No.
Belumosudil mesylate Chemical Structure
BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively). Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
D-erythro-Sphingosine HCl Chemical Structure
BCP40404 D-erythro-Sphingosine HCl 2637-72-5
D-erythro-Sphingosine is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
HS-243 Chemical Structure
BCP39678 HS-243 848249-10-5
HS-243 is an inhibitor of transforming growth factor-?beta kinase.
Phorbol 12,13-dibutyrate Chemical Structure
BCP38374 Phorbol 12,13-dibutyrate 37558-16-0
Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter.
CMPD101 Chemical Structure
BCP37871 CMPD101 865608-11-3
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC50s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.
BMP signaling agonist sb4 Chemical Structure
BCP37563 BMP signaling agonist sb4 100874-08-6
BMP signaling agonist sb4 is a potent and selective BMP4 signaling agonist with EC50 value of 74 nM. It enhances canonical BMP signaling and activates SMAD-1/5/9 phosphorylation.
Hispidin Chemical Structure
BCP34507 Hispidin 555-55-5
Hispidin, a PKC inhibitor and a phenolic compound from Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties.
TC-S 7001 Chemical Structure
BCP34134 TC-S 7001 867017-68-3
TC-S 7001 is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1?nM for human ROCK-1 and ROCK-2, respectively.
Y-27632  Dihydrochloride Hydrate Chemical Structure
BCP26044 Y-27632 Dihydrochloride Hydrate 331752-47-7
Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
LDN-212854 Chemical Structure
BCP14671 LDN-212854 143259726-6
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2.
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