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Topoisomerase

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Topoisomerase

Chemical Structure Cat. No. Product Name CAS No.
Berubicin Chemical Structure
BCP41505 Berubicin 677017-23-1
Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
Rebeccamycin Chemical Structure
BCP41470 Rebeccamycin 93908-02-2
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I.
Chimmitecan Chemical Structure
BCP40436 Chimmitecan 185425-25-6
Chimmitecan is a potent topoisomerase I inhibitor.
Namitecan Chemical Structure
BCP36777 Namitecan 372105-27-6
Namitecan is a potent topoisomerase I inhibitor, with antitumor property.
Exatecan mesylate dihydrate Chemical Structure
BCP36302 Exatecan mesylate dihydrate 197720-53-9
Exatecan Mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
Phenoxodiol Chemical Structure
BCP34699 Phenoxodiol 81267-65-4
Phenoxodiol inhibits XIAP (an apoptosis inhibitor) and DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol activates the mitochondrial caspase system and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol is a synthetic analog of Genestein.
LMP744 Chemical Structure
BCP34017 LMP744 308246-52-8
LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
LMP744 hydrochloride Chemical Structure
BCP34016 LMP744 hydrochloride 308246-57-3
LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
Indotecan Chemical Structure
BCP34018 Indotecan 915303-09-2
Indotecan is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity. Indotecan is currently in Phase I trials.
Chebulanin Chemical Structure
BCP28487 Chebulanin 166833-80-3
Chebulanin is isolated and purified from the fruits of Terminalia chebula
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