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Wnt/Stem Cell

Chemical Structure Cat. No. Product Name CAS No.
Belumosudil mesylate Chemical Structure
BCP41838 Belumosudil mesylate 2109704-99-4
Belumosudil mesylate is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50s = 105 nM and 24 μM, respectively). Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. Belumosudil (KD025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion.
IWP-O1 Chemical Structure
BCP41115 IWP-O1 2074607-48-8
IWP-O1 is a potent porcupine inhibitor that blocks Wnt signaling in L-Wnt-STF cells with EC50 value of 80 pM. IWP-O1 can affect differentiation of hESC.
I3MT-3 Chemical Structure
BCP40982 I3MT-3 459420-09-8
I3MT-3 is a novel potent and selective inhibitor of 3-mercaptopyruvate sulfurtransferase (3-MST).
SHR0302 Chemical Structure
BCP34833 SHR0302 1445987-21-2
SHR0302 is a novel potent JAK inhibitor, blocking JAK/STAT3 signaling, suppressing proliferation, migration and collagen production, and inducing the apoptosis of hepatic stellate cells.
SI-109 Chemical Structure
BCP40461 SI-109 2429877-30-3
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM).
PRI-724 Chemical Structure
BCP39699 PRI-724 1198780-43-6
PRI-724, an isomer or enantiomer of ICG-001, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.
HS-243 Chemical Structure
BCP39678 HS-243 848249-10-5
HS-243 is an inhibitor of transforming growth factor-?beta kinase.
Silmitasertib sodium Chemical Structure
BCP38774 Silmitasertib sodium 1309357-15-0
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Pyrvinium pamoate Chemical Structure
BCP38435 Pyrvinium pamoate 3546-41-6
Pyrvinium pamoate is a naphthoic acid. It has a role as an anticoronaviral agent.
MYF-01-37 Chemical Structure
BCP33331 MYF-01-37 2416417-65-5
MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
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